Supporting successful astronomical missions requires more than brighter minds with a vision. It requires a strong team from a wide variety of disciplines working together towards a common goal: support the Space Telescope Science Institute (STScI) missions and excel while doing it. Here I present the main steps we have taken to meet the challenges ahead, with special attention to the combined effort between scientists and developers, along with an overview of the projects currently under the purview of the Mission Engineering and Science Analysis (MESA) group at the STScI.