The first enantiomerically pure synthesis of (S)- and (R)-Naftopidil utilizing Hydrolytic Kinetic Resolution of (±)-(α-naphthyl) glycidyl ether

被引：10

作者：

Kothakonda, KK ^{[1
]}

Bose, DS

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

[2] Chem Ind Inst Toxicol, Fine Chem Lab, Hyderabad, Andhra Pradesh, India

来源：

CHEMISTRY LETTERS | 2004年 / 33卷 / 09期

关键词：

D O I：

10.1246/cl.2004.1212

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrolytic Kinetic Resolution (HKR) of (+/-)-(alpha-Naphthyl) glycidyl ether with (R,R)-salen Co(III) OAc complex provided enatiomerically pure (S)-naphthyl glycidyl ether and (R)-1-naphthyl glycerol; opening of the corresponding pure terminal epoxide with 1-(2-methoxyphenyl)piperizine gave the enantiomerically pure (S)- and (R)-Naftopidil.

引用

页码：1212 / 1213

页数：2

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