Asymmetric synthesis of (S)-vigabatrin® and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides

被引：15
|
作者：
Raj, I. Victor Paul [1 ]
Sudalai, A. [1 ]
机构：
[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 16期
关键词：
D O I：
10.1016/j.tetlet.2008.02.064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise route to the asymmetric synthesis of (S)-vigabatrin(R) and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2646 / 2648
页数：3
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