TOWARDS PERSONALIZED MEDICINE USING A NOVEL PRECLINICAL MODEL: IDENTIFYING DARATUMUMAB AS EFFECTIVE TREATMENT FOR MULTIPLE MYELOMA

被引:0
|
作者
Noort, W. [1 ]
Groen, R. [1 ]
Raymakers, R. [1 ]
Prins, H. [1 ]
Aalders, L. [1 ]
Hofhuis, F. [1 ]
van Kessel, B. [1 ]
Moerer, P. [1 ]
Rozemuller, H. [1 ]
de Bruijn, J. [2 ]
de Weers, M. [3 ]
Schuringa, J. [1 ]
Parren, P. [3 ]
Lokhorst, H. [1 ]
Mutis, T. [1 ]
Martens, A. [1 ]
机构
[1] Univ Med Ctr, Utrecht, Netherlands
[2] Queen Mary Univ London, Sch Engn & Mat Sci, London, England
[3] Genmab BV, Utrecht, Netherlands
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1075
引用
收藏
页码:438 / 438
页数:1
相关论文
共 50 条
  • [41] Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Refractory Patient-Derived Multiple Myeloma Cells, Growing in a Novel Humanized Mouse MM Model
    Noort, Willy A.
    Groen, Richard W. J.
    Raymakers, Reinier
    Aalders, Linda
    Hofhuis, Frans M.
    Van Kessel, Berris
    Van Velzen, Jeroen F.
    de Bruijn, Joost
    Yuan, Huipin
    van Bueren, Jeroen Lammerts
    Bloem, Andries C.
    Parren, Paul W. H. I.
    Lokhorst, Henk
    Mutis, Tuna
    Martens, Anton C. M.
    BLOOD, 2012, 120 (21)
  • [42] Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model
    Ji, Bing
    Yang, Qing
    Genever, Paul G.
    Fagan, Michael J.
    BIO-MEDICAL MATERIALS AND ENGINEERING, 2014, 24 (06) : 3373 - 3378
  • [43] Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model
    Reagan, Michaela R.
    Mishima, Yuji
    Glavey, Siobhan V.
    Zhang, Yong
    Manier, Salomon
    Lu, Zhi Ning
    Memarzadeh, Masoumeh
    Zhang, Yu
    Sacco, Antonio
    Aljawai, Yosra
    Shi, Jiantao
    Tai, Yu-Tzu
    Ready, John E.
    Kaplan, David L.
    Roccaro, Aldo M.
    Ghobrial, Irene M.
    BLOOD, 2014, 124 (22) : 3250 - 3259
  • [44] Towards Effective Shared Decision Making - Development and Validation of a Prediction Model for Personalized Probabilities of Side Effects in the Initial Treatment of Juvenile Idiopathic Arthritis
    Park, Jonathan
    Loughin, Thomas
    Henrey, Andrew
    Guzman, Jaime
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 679 - 681
  • [45] A novel T cell engager targeting BCMA and GPRC5D showed promising preclinical activity with low toxic risk for multiple myeloma treatment
    Fu, Yayuan
    You, Shumei
    Wei, Menghao
    Yin, Bowei
    Deng, Qi
    Qin, Xiaokang
    Zhang, Yun
    Wang, Yanqiu
    Tang, Renhong
    CANCER RESEARCH, 2023, 83 (07)
  • [46] Preclinical validation of a clinical grade novel specific small molecule cyclin D1 inhibitor, P276-00 for the treatment of multiple myeloma
    Raje, Noopur
    Hideshima, Teru
    Vallet, Sonia
    Cirstea, Diana
    Kiziltepe, Tanyel
    Chhetri, Shweta
    Mani, Mala
    Mukherjee, Siddhartha
    Carrasco, Daniel Ruben
    Mitsiades, Constantine
    Rooney, Melissa
    Podar, Klaus
    Okawa, Yutaka
    Ikeda, Hiroshi
    Richardson, Paul G.
    Chauhan, Dharminder
    Munshi, Nikhil C.
    Sharma, Somesh
    Parikh, Himanshu
    Chabner, Bruce
    Anderson, Kenneth C.
    BLOOD, 2007, 110 (11) : 82A - 83A
  • [47] Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM
    Maclachlan, Kylee H.
    Cuddihy, Andrew
    Hein, Nadine
    Cullinane, Carleen
    Harrison, Simon J.
    Hannan, Ross
    Poortinga, Gretchen
    BLOOD, 2018, 132
  • [48] IN-VITRO AND IN-VIVO ASSESSMENT OF CYTOKINES AND CYTOTOXIC DRUGS FOR THE TREATMENT OF MULTIPLE-MYELOMA USING A MURINE MODEL
    LEAHY, MF
    MANNING, LS
    CHAMBERLAIN, NL
    CORDINGLEY, FT
    JOURNAL OF LEUKOCYTE BIOLOGY, 1993, : 88 - 88
  • [49] Innovative Statistical Model Uncover Effective Herbal Medicines Among Personalized Treatment Plans in Persian Medicine: A Small-Scale Study in Type 2 Diabetes
    Eftekhari Mahabadi, Samaneh
    Khalifeh, Reza
    Ghods, Roshanak
    Wieland, L. Susan
    Ghelman, Ricardo
    Shojaii, Asie
    Zareian, Armin
    Hosseini Yekta, Nafiseh
    JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE, 2024, 30 (12): : 1217 - 1230
  • [50] Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease.
    Pozzi, Samantha
    Yan, Hua
    Vallet, Sonia
    Vaghela, Nileshwari
    Fulciniti, Mariateresa
    Cirstea, Diana
    Santo, Loredana
    Mukherjee, Siddhartha
    Hideshima, Teru
    Schirtzinger, Linda
    Kuhstoss, Stuart
    Munshi, Nikhil C.
    Anderson, Kenneth C.
    Scadden, David
    Raje, Noopur
    BLOOD, 2008, 112 (11) : 946 - 946