Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Refractory Patient-Derived Multiple Myeloma Cells, Growing in a Novel Humanized Mouse MM Model

被引：4

作者：

Noort, Willy A. ^{[1
]}

Groen, Richard W. J. ^{[1
]}

Raymakers, Reinier ^{[1
]}

Aalders, Linda ^{[1
]}

Hofhuis, Frans M. ^{[1
]}

Van Kessel, Berris ^{[1
]}

Van Velzen, Jeroen F. ^{[1
]}

de Bruijn, Joost ^{[2
]}

Yuan, Huipin ^{[3
]}

van Bueren, Jeroen Lammerts ^{[4
]}

Bloem, Andries C. ^{[1
]}

Parren, Paul W. H. I. ^{[4
]}

Lokhorst, Henk ^{[1
]}

Mutis, Tuna ^{[1
]}

Martens, Anton C. M. ^{[1
]}

机构：

[1] UMC Utrecht, Utrecht, Netherlands

[2] Xpand Biotechnol, Bilthoven, Netherlands

[3] Xpand Biotechnol BV, Bilthoven, Netherlands

[4] Genmab BV, Utrecht, Netherlands

来源：

BLOOD | 2012年 / 120卷 / 21期

关键词：

D O I：

10.1182/blood.V120.21.940.940

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

940

引用

页数：2

共 41 条

[1] Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
de Weers, Michel
Tai, Yu-Tzu
van der Veer, Michael S.
Bakker, Joost M.
Vink, Tom
Jacobs, Danielle C. H.
Oomen, Lukas A.
Peipp, Matthias
Valerius, Thomas
Slootstra, Jerry W.
Mutis, Tuna
Bleeker, Wim K.
Anderson, Kenneth C.
Lokhorst, Henk M.
van de Winkel, Jan G. J.
Parren, Paul W. H. I.
JOURNAL OF IMMUNOLOGY, 2011, 186 (03): : 1840 - 1848
[2] Daratumumab, a Novel Potent Human Anti-CD38 Monoclonal Antibody, Induces Significant Killing of Human Multiple Myeloma Cells: Therapeutic Implication
Tai, Yu-Tzu
de Weers, Michel
Li, Xian-Feng
Song, Weihua
Nahar, Sabikun
Bakker, Joost M.
Vink, Tom
Jacobs, Danielle
Oomen, Lukas
Bleeker, Wim K.
Munshi, Nikhil C.
van de Winkel, Jan G. J.
Parren, Paul W. H. I.
Richardson, Paul
Anderson, Kenneth C.
BLOOD, 2009, 114 (22) : 252 - 252
[3] A novel therapeutic monoclonal antibody, Daratumumab, in refractory multiple myeloma
Richez, Valentine
Legros, Laurence
Leleu, Xavier
HEMATOLOGIE, 2016, 22 (03): : 180 - 180
[4] Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Moreau, Philippe
van de Donk, Niels W. C. J.
Miguel, Jesus San
Lokhorst, Henk
Nahi, Hareth
Ben-Yehuda, Dina
Cavo, Michele
Cook, Gordon
Delforge, Michel
Einsele, Hermann
Zweegman, Sonja
Ludwig, Heinz
Driessen, Christoph
Palumbo, Antonio
Facon, Thierry
Plesner, Torben
Dimopoulos, Meletios
Sondergeld, Pia
Sonneveld, Pieter
Mateos, Maria-Victoria
DRUGS, 2016, 76 (08) : 853 - 867
[5] Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Philippe Moreau
Niels W. C. J. van de Donk
Jesus San Miguel
Henk Lokhorst
Hareth Nahi
Dina Ben-Yehuda
Michele Cavo
Gordon Cook
Michel Delforge
Hermann Einsele
Sonja Zweegman
Heinz Ludwig
Christoph Driessen
Antonio Palumbo
Thierry Facon
Torben Plesner
Meletios Dimopoulos
Pia Sondergeld
Pieter Sonneveld
María-Victoria Mateos
Drugs, 2016, 76 : 853 - 867
[6] Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Philippe Moreau
Niels W. C. J. van de Donk
Jesus San Miguel
Henk Lokhorst
Hareth Nahi
Dina Ben-Yehuda
Michele Cavo
Gordon Cook
Michel Delforge
Hermann Einsele
Sonja Zweegman
Heinz Ludwig
Christoph Driessen
Antonio Palumbo
Thierry Facon
Torben Plesner
Meletios Dimopoulos
Pia Sondergeld
Pieter Sonneveld
María-Victoria Mateos
Drugs, 2016, 76 : 989 - 990
[7] Towards Effective Immunotherapy of Multiple Myeloma: Enhanced Elimination of Myeloma Cells by Combination of Lenalidomide with the Human CD38 Monoclonal Antibody Daratumumab
van der Veer, Michael S.
de Weers, Michel
van Kessel, Berris
Wittebol, Shulamiet
Bakker, Joost M.
Parren, Paul W. H. I.
Lokhorst, Henk M.
Mutis, Tuna
BLOOD, 2010, 116 (21) : 1262 - 1262
[8] TAK-169, a Novel Recombinant Immunotoxin Specific for CD38, Induces Powerful Preclinical Activity Against Patient-Derived Multiple Myeloma Cells
Bruins, Wassilis S. C.
Zheng, Wenrou
Higgins, Jack P.
Willert, Erin K.
Newcomb, John
Dash, Ajeeta B.
Van de Donk, Niels W. C. J.
Zweegman, Sonja
Mutis, Tuna
BLOOD, 2020, 136
[9] Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab
van der Veer, Michael. S.
de Weers, Michel
van Kessel, Berris
Bakker, Joost M.
Wittebol, Shulamiet
Parren, Paul W. H. I.
Lokhorst, Henk M.
Mutis, Tuna
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (02): : 284 - 290
[10] Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma (vol 76, pg 853, 2016)
Moreau, Philippe
van de Donk, Niels W. C. J.
San Miguel, Jesus
Lokhorst, Henk
Nahi, Hareth
Ben-Yehuda, Dina
Cavo, Michele
Cook, Gordon
Delforge, Michel
Einsele, Hermann
Zweegman, Sonja
Ludwig, Heinz
Driessen, Christoph
Palumbo, Antonio
Facon, Thierry
Plesner, Torben
Dimopoulos, Meletios
Sondergeld, Pia
Sonneveld, Pieter
Mateos, Maria-Victoria
DRUGS, 2016, 76 (09) : 989 - 990

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