Iodine (III)-mediated synthesis of some 2-aryl/hetarylbenzoxazoles as antibacterial/antifungal agents

被引：7

作者：

Kumar, Ravi ^{[1
]}

Nair, Reshmi R. ^{[1
]}

Dhiman, Saurabh Sudha ^{[2
]}

Sharma, Jitender ^{[2
]}

Prakash, Om ^{[1
]}

机构：

[1] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India

[2] Kurukshetra Univ, Dept Biotechnol, Kurukshetra 136119, Haryana, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 06期

关键词：

Iodobenzene diacetate; Schiff bases; 2-hetarylbenzoxazoles; Antibacterial activity; Antifungal activity; HETEROCYCLIC-COMPOUNDS; OXIDATIVE CYCLIZATION; SCHIFFS BASES; ORGANIC-SYNTHESIS; 2-ARYLBENZOXAZOLES; REAGENTS; <HYDROXY(TOSYLOXY)IODO>BENZENE; BENZOXAZOLES; INHIBITORS;

D O I：

10.1007/s00044-009-9211-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were synthesized via oxidative cyclization of Schiff bases (3a, 3b, and 4a-h) with 1.1 equivalent of iodobenzene diacetate (IBD) in methanol. All of these 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were tested in vitro for their antibacterial and antifungal activities against Bacillus subtilis, Bacillus stearothermophilus, Escherichia coli, and Pseudomonas putida. These compounds also were screened for their antifungal activity against Aspergillus flavus and Aspergillus niger. Biological activity of these compounds was compared with those of commercially available antibiotics, chloramphenicol and antifungal agent cycloheximide. Most of these compounds, 5a, 5b, 6a, 6b, 6d, 6e, 6g, 6h, were equipotent or more potent than these commercial drugs at concentration 100 mu g/ml.

引用

页码：541 / 550

页数：10

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