Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

被引：7

作者：

Chen, Weizhen ^{[1
]}

Wang, Guokai ^{[2
]}

Mei, Ke ^{[3
]}

Zhu, Jianyong ^{[4
]}

机构：

[1] Huangshan Vocat & Tech Coll, Dept Med, Huangshan 245000, Anhui, Peoples R China

[2] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Anhui, Peoples R China

[3] Dahua Hosp Xuhui Dist, Shanghai 200237, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Shanghai 200137, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2021年 / 15卷 / 05期

关键词：

Angelica dahurica; coumarin; apoptosis; cytotoxicity; BARK;

D O I：

10.25135/rnp.225.21.01.1935

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumarin, angedahurin A (1), and seven known analogues (2-8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1-8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2.M,for comparison, the positive control, 5-FU, had an IC50 value of 32.4. M. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.

引用

页码：356 / 362

页数：7

共 50 条

[31] Human MG-63 osteosarcoma cells responses to long and short term hyper- and hypothermia stress
Nashiry, Mohammed Ali O.
AL-Khateeb, Alyaa R.
Keong, Yeap S.
Froemming, Gabriele R. A.
MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES, 2020, 16 (05): : 585 - 596
[32] Effects of Indomethacin, Nimesulide, and Diclofenac on Human MG-63 Osteosarcoma Cell Line
Diaz-Rodriguez, Lourdes
Garcia-Martinez, Olga
Arroyo-Morales, Manuel
Rodriguez-Perez, Laura
Rubio-Ruiz, Belen
Ruiz, Concepcion
BIOLOGICAL RESEARCH FOR NURSING, 2012, 14 (01) : 98 - 107
[33] Glycosaminoglycan sugars are essential for in vitro proliferation and mineralization of MG-63 osteosarcoma cells
Kumarasuriyar, A.
Hin, I. Lee Hock
Murali, S.
Nurcombe, V.
Cool, S.
BONE, 2006, 39 (05) : S5 - S5
[34] Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells
Hu, Youzhen
Chen, Ling
Yi, Chengzhi
Yang, Fan
Chen, Jige
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2012, 32 (04) : 581 - 585
[35] Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells
Youzhen Hu
Ling Chen
Chengzhi Yi
Fan Yang
Jige Chen
Journal of Huazhong University of Science and Technology [Medical Sciences], 2012, 32 : 581 - 585
[36] Characterization of the glutametergic system in MG-63 osteoblast-like osteosarcoma cells
Kalariti, N
Lembessis, P
Koutsilieris, M
ANTICANCER RESEARCH, 2004, 24 (06) : 3923 - 3929
[37] The expression and regulation of IL-1 beta mRNA in human osteosarcoma MG-63 cells.
Min, YK
Voznesensky, O
Raisz, LG
Pilbeam, CC
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 : S320 - S320
[38] Insulin Regulates GLUT1-Mediated Glucose Transport in MG-63 Human Osteosarcoma Cells
Cifuentes, Manuel
Garcia, Maria A.
Arrabal, Pilar M.
Martinez, Fernando
Yanez, Maria J.
Jara, Nery
Weil, Bernardo
Dominguez, Dolores
Medina, Rodolfo A.
Nualart, Francisco
JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (06) : 1425 - 1432
[39] Biological Characteristics of the MG-63 Human Osteosarcoma Cells on Composite Tantalum Carbide/Amorphous Carbon Films
Chang, Yin-Yu
Huang, Heng-Li
Chen, Ya-Chi
Hsu, Jui-Ting
Shieh, Tzong-Ming
Tsai, Ming-Tzu
PLOS ONE, 2014, 9 (04):
[40] Transglutaminase-2 Is Involved in Expression of Osteoprotegerin in MG-63 Osteosarcoma Cells
Lee, Hye Ja
Lee, Chang Hoon
BIOMOLECULES & THERAPEUTICS, 2013, 21 (03) : 204 - 209

← 1 2 3 4 5 →