Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

被引：7
|
作者：
Chen, Weizhen [1 ]
Wang, Guokai [2 ]
Mei, Ke [3 ]
Zhu, Jianyong [4 ]
机构：
[1] Huangshan Vocat & Tech Coll, Dept Med, Huangshan 245000, Anhui, Peoples R China
[2] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Anhui, Peoples R China
[3] Dahua Hosp Xuhui Dist, Shanghai 200237, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Shanghai 200137, Peoples R China
来源：
RECORDS OF NATURAL PRODUCTS | 2021年 / 15卷 / 05期
关键词：
Angelica dahurica; coumarin; apoptosis; cytotoxicity; BARK;
D O I：
10.25135/rnp.225.21.01.1935
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new coumarin, angedahurin A (1), and seven known analogues (2-8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1-8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2.M,for comparison, the positive control, 5-FU, had an IC50 value of 32.4. M. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.
引用
收藏
页码：356 / 362
页数：7
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