Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

被引：7

作者：

Chen, Weizhen ^{[1
]}

Wang, Guokai ^{[2
]}

Mei, Ke ^{[3
]}

Zhu, Jianyong ^{[4
]}

机构：

[1] Huangshan Vocat & Tech Coll, Dept Med, Huangshan 245000, Anhui, Peoples R China

[2] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Anhui, Peoples R China

[3] Dahua Hosp Xuhui Dist, Shanghai 200237, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Shanghai 200137, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2021年 / 15卷 / 05期

关键词：

Angelica dahurica; coumarin; apoptosis; cytotoxicity; BARK;

D O I：

10.25135/rnp.225.21.01.1935

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumarin, angedahurin A (1), and seven known analogues (2-8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1-8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2.M,for comparison, the positive control, 5-FU, had an IC50 value of 32.4. M. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.

引用

页码：356 / 362

页数：7

共 50 条

[1] Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells
Qin, Ya-Dong
Fang, Feng-Man
Zhou, Juan-Juan
Wang, Rong-Bin
Xu, Sheng-Xiang
Li, Lin-hua
Zhang, Han-Lin
FITOTERAPIA, 2020, 146
[2] Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities
Bai, Yan
Li, Dahong
Zhou, Tingting
Qin, Ningbo
Li, Zhanlin
Yu, Zhiguo
Hua, Huiming
JOURNAL OF FUNCTIONAL FOODS, 2016, 20 : 453 - 462
[3] Astaxanthin Induces Apoptosis in Human Osteosarcoma MG-63 Cells
Wang, Guangyu
Tian, Xu
Liu, Lintao
Dong, Jingming
FOLIA BIOLOGICA, 2023, 69 (5-6) : 186 - 193
[4] Mechanisms of the Action of Zoledronic Acid on Human MG-63 Osteosarcoma Cells
Tenta, R.
Pitulis, N.
Tiblalexi, D.
Consoulas, C.
Katopodis, H.
Konstantinidou, E.
Manoussakis, M.
Kletsas, D.
Alexis, M. N.
Poyatzi, A.
Koutsilieris, M.
HORMONE AND METABOLIC RESEARCH, 2008, 40 (11) : 737 - 745
[5] Cytotoxic Coumarins from the root of Angelica dahurica
Thanh, PN
Jin, WY
Song, GY
Bae, KH
Kang, SS
ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (12) : 1211 - 1215
[6] Mesenchymal to epithelial transition in osteosarcoma MG-63 cells
Niinaka, Yasufumi
Nakano, Yoshio
Higuchi, Masatoshi
Oda, Mitsumasa
Harada, Kiyoshi
CANCER RESEARCH, 2009, 69
[7] Heparin modulates human osteosarcoma (MG-63) activities on collagen-coated substrata
Tsai, SW
Cheng, YH
Tsai, WB
JOURNAL OF THE CHINESE INSTITUTE OF CHEMICAL ENGINEERS, 2005, 36 (06): : 661 - 668
[8] Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts
Munoz, Miguel
Berger, Michael
Rosso, Marisa
Gonzalez-Ortega, Ana
Carranza, Andres
Covenas, Rafael
INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (01) : 137 - 146
[9] Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells
Zou, Yonggen
Yang, Jiexiang
Jiang, Dianming
MOLECULAR MEDICINE REPORTS, 2015, 12 (05) : 7221 - 7226
[10] Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells
Zhu, Yu
Ma, Nan
Li, Hui-Xiang
Tian, Lin
Ba, Yu-Feng
Hao, Bin
MOLECULAR MEDICINE REPORTS, 2014, 10 (04) : 1734 - 1738

← 1 2 3 4 5 →