Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers

被引：6

作者：

Saletti, Mario ^{[1
]}

Paolino, Marco ^{[1
]}

Ballerini, Lavinia ^{[1
]}

Giuliani, Germano ^{[1
]}

Leone, Gemma ^{[1
]}

Lamponi, Stefania ^{[1
]}

Andreassi, Marco ^{[1
]}

Bonechi, Claudia ^{[1
]}

Donati, Alessandro ^{[1
]}

Piovani, Daniele ^{[2
]}

Schieroni, Alberto Giacometti ^{[2
]}

Magnani, Agnese ^{[1
]}

Cappelli, Andrea ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Biotecnol Chim & Farm Dipartimento E, Via Aldo Moro 2, I-53100 Siena, Italy

[2] Ist Sci & Tecnol Chim G Natta SCITEC CNR, Via A Corti 12, I-20133 Milan, Italy

来源：

PHARMACEUTICS | 2022年 / 14卷 / 05期

关键词：

hyaluronic acid; ferulic acid; click-chemistry; crosslinking; hydrogel; FERULIC ACID; CELL; STATES; WALLS; WATER;

D O I：

10.3390/pharmaceutics14051041

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.

引用

页数：24

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