Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus

被引：44
|
作者：
Baltch, Aldona L. [1 ]
Ritz, William J.
Bopp, Lawrence H.
Michelsen, Phyllis B.
Smith, Raymond P.
机构：
[1] Stratton VA Med Ctr, Infect Dis Sect 111D, Albany, NY 12208 USA
[2] Albany Med Coll, Albany, NY 12208 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
D O I：
10.1128/AAC.00973-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the anti staphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of daptomycin, gentamicin, and rifampin was most effective intracellularly, while daptomycin plus gentamicin and the three-drug combination were most effective extracellularly, completely eliminating viable Staphylocorcus aureus.
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页码：1559 / 1562
页数：4
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