Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E-coli

被引:7
|
作者
Han, Jennifer H. [1 ,2 ,3 ]
Johnston, Brian [5 ,6 ]
Nachamkin, Irving [4 ]
Tolomeo, Pam [2 ]
Bilker, Warren B. [2 ,3 ]
Mao, Xiangqun [2 ]
Clabots, Connie [5 ,6 ]
Lautenbach, Ebbing [1 ,2 ,3 ]
Johnson, James R. [5 ,6 ]
机构
[1] Univ Penn, Dept Med, Div Infect Dis, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[5] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA
[6] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
基金
美国国家卫生研究院;
关键词
RISK-FACTORS; ST131; INFECTIONS; DOMINANT; STRAINS; B2;
D O I
10.1128/AAC.03256-14
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
This study examined molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among hospitalized patients colonized intestinally with fluoroquinolone (FQ)-resistant E. coli between 2002 and 2004. Among 86 patients, 21 (24%) were colonized with ST131. The proportion of ST131 isolates among colonizing isolates increased significantly over time, from 8% in 2002 to 50% in 2004 (P = 0.003). Furthermore, all 19 clonally related isolates were ST131. Future studies should identify potential transmissibility differences between ST131 and non-ST131 strains.
引用
收藏
页码:7003 / 7006
页数:4
相关论文
共 50 条
  • [21] Clinical Impact of Fluoroquinolone-Resistant Escherichia coli in the Fecal Flora of Hematological Patients with Neutropenia and Levofloxacin Prophylaxis
    Chong, Yong
    Shimoda, Shinji
    Yakushiji, Hiroko
    Ito, Yoshikiyo
    Aoki, Takatoshi
    Miyamoto, Toshihiro
    Kamimura, Tomohiko
    Shimono, Nobuyuki
    Akashi, Koichi
    PLOS ONE, 2014, 9 (01):
  • [22] MUTATIONS IN THE GYRA GENE OF A HIGHLY FLUOROQUINOLONE-RESISTANT CLINICAL ISOLATE OF ESCHERICHIA-COLI
    HEISIG, P
    SCHEDLETZKY, H
    FALKENSTEINPAUL, H
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) : 696 - 701
  • [23] gyrA mutations in high-level fluoroquinolone-resistant clinical isolates of Escherichia coli
    Conrad, S
    Oethinger, M
    Kaifel, K
    Klotz, G
    Marre, R
    Kern, WV
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 (03) : 443 - 455
  • [24] Gastrointestinal Tract Colonization With Fluoroquinolone-Resistant Escherichia coli in Hospitalized Patients: Changes Over Time in Risk Factors for Resistance
    Lautenbach, Ebbing
    Metlay, Joshua P.
    Weiner, Mark G.
    Bilker, Warren B.
    Tolomeo, Pam
    Mao, Xiangqun
    Nachamkin, Irving
    Fishman, Neil O.
    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2009, 30 (01): : 18 - 24
  • [25] Prevalence and Molecular Characterization of Fluoroquinolone-Resistant Escherichia coli Isolated from Diarrheic Cattle in Korea
    Lim, Suk-Kyung
    Lim, Keum-Gi
    Lee, Hee-Soo
    Jung, Suk-Chan
    Kang, Mun-Il
    Nam, Hyang-Mi
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2010, 72 (05): : 611 - 614
  • [26] Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli (vol 59, pg 4471, 2015)
    Johnson, James R.
    Johnston, Brian
    Kuskowski, Michael A.
    Sokurenko, Evgeni V.
    Tchesnokova, Veronika
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (09) : 5871 - 5871
  • [27] 1ST CLINICAL ISOLATE OF HIGHLY FLUOROQUINOLONE-RESISTANT ESCHERICHIA-COLI IN SCANDINAVIA
    JONSSON, M
    WALDER, M
    FORSGREN, A
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1990, 9 (11) : 851 - 853
  • [28] Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens
    Yoon, Mi Young
    Kim, Yeong Bin
    Ha, Jong Su
    Seo, Kwang Won
    Noh, Eun Bi
    Son, Se Hyun
    Lee, Young Ju
    POULTRY SCIENCE, 2020, 99 (07) : 3628 - 3636
  • [29] Clonal group distribution of fluoroquinolone-resistant Escherichia coli among humans and companion animals in Australia
    Platell, Joanne L.
    Cobbold, Rowland N.
    Johnson, James R.
    Trott, Darren J.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (09) : 1936 - 1938
  • [30] Escherichia coli Bloodstream Infection After Transrectal Ultrasound-Guided Prostate Biopsy: Implications of Fluoroquinolone-Resistant Sequence Type 131 as a Major Causative Pathogen
    Williamson, Deborah A.
    Roberts, Sally A.
    Paterson, David L.
    Sidjabat, Hanna
    Silvey, Anna
    Masters, Jonathan
    Rice, Michael
    Freeman, Joshua T.
    CLINICAL INFECTIOUS DISEASES, 2012, 54 (10) : 1406 - 1412