The TCF7L2 Gene Polymorphisms and the Relationship between TCF7L2 Gene and Type 2 Diabetes: A review

被引：0
|
作者：
Zhang Zhong [1 ]
Xie Yue [1 ]
Gao Zhi-Mou [1 ]
机构：
[1] Maoming Univ, Coll Chem & Life Sci, Maoming 525000, Peoples R China
来源：
PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 | 2009年
关键词：
type; 2; diabetes; TCF7L2; rs7903146; rs12255372; mechanism; INSULIN-SECRETION; RISK; VARIANTS; WNT; ASSOCIATION; PROINSULIN; EXPRESSION; SUSCEPTIBILITY; REPLICATION; MECHANISMS;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Emerging evidence indicates that,variation in the transcription factor 7-like 2(TCF7L2) gene may play a role in the pathogenesis of type 2 diabetes. The paper was to focus on review the polymorphisms of transcription factor 7-like-2 (TCF7L2) and the possible mechanism that TCF7L2 causes type 2 diabetes. The genetic effects of TCF7L2 have been replicated with remarkable consistency across various populations and stand out as having by far the biggest effect on diabetes risk. There are five single nucleotide polymorphisms (SNPs) of TCF7L2 connecting with Type 2 diabetes, especially the two SNPs (rs7903146 and rs12255372), which have been confirmed in many experiments. The possible mechanism that TCF7L2 causes type 2 diabetes may help to treat and restrain type 2 diabetes.
引用
收藏
页码：377 / 383
页数：7
相关论文
共 50 条
  • [41] Emergence of TCF7L2 as a most promising gene in predisposition of diabetes type II
    Gupta, Vipin
    Khadgawat, Rajesh
    Saraswathy, K. N.
    Sachdeva, M. P.
    Kalla, A. K.
    INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2008, 8 (1-2) : 199 - 215
  • [42] TCF7L2 and type 2 diabetes—we WNT to know
    U. Smith
    Diabetologia, 2007, 50 : 5 - 7
  • [43] Redundant enhancers and causal variants in the TCF7L2 gene
    Edward A Ruiz-Narváez
    European Journal of Human Genetics, 2014, 22 : 1243 - 1246
  • [44] Testing the gene or testing a variant? The case of TCF7L2
    Goodarzi, Mark O.
    Rotter, Jerome I.
    DIABETES, 2007, 56 (10) : 2417 - 2419
  • [45] Redundant enhancers and causal variants in the TCF7L2 gene
    Ruiz-Narvaez, Edward A.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2014, 22 (11) : 1243 - 1246
  • [46] Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population
    Dan Ye
    Yang Fei
    Qi Ling
    Weiwei Xu
    Zhe Zhang
    Jing Shu
    Chengjiang Li
    Fengqin Dong
    Scientific Reports, 6
  • [47] TRANSCRIPTION FACTOR 7-LIKE 2 (TCF7L2): A CULPRIT GENE IN TYPE 2 DIABETES MELLITUS
    Jan, Asif
    Jan, Humerah
    Ullah, Zaki
    DIABETES MELLITUS, 2021, 24 (04): : 371 - 376
  • [48] Correlation between TCF7L2 gene expression and certain biochemical parameters in type 2 diabetes mellitus
    Younus, Alaa H.
    Al-Faisal, Abdul Hussein M.
    JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES, 2024, 19 (03): : 575 - 584
  • [49] Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type 2 diabetes in Sudan
    Ibrahim A.T.
    Hussain A.
    Salih M.A.M.
    Ibrahim O.A.
    Jamieson S.E.
    Ibrahim M.E.
    Blackwell J.M.
    Mohamed H.S.
    Journal of Diabetes & Metabolic Disorders, 15 (1):
  • [50] Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population
    Ye, Dan
    Fei, Yang
    Ling, Qi
    Xu, Weiwei
    Zhang, Zhe
    Shu, Jing
    Li, Chengjiang
    Dong, Fengqin
    SCIENTIFIC REPORTS, 2016, 6
12345