Protein tyrosine phosphatase PTPN22 in human autoimmunity

被引：128
|
作者：
Vang, Torkel
Miletic, Ana V.
Bottini, Nunzio
Mustelin, Tomas
机构：
[1] Burnham Inst Med Res, La Jolla, CA 92037 USA
[2] Univ So Calif, Inst Med Genet, Keck Sch Med, Los Angeles, CA 90033 USA
[3] Amgen Inc, Seattle, WA 98119 USA
来源：
AUTOIMMUNITY | 2007年 / 40卷 / 06期
关键词：
protein tyrosine phosphatase; human autoimmunity; Graves' disease; rheumatoid arthritis; type; 1; diabetes;
D O I：
10.1080/08916930701464897
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The discovery that a single-nucleotide polymorphism ( SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1 diabetes (T1D) has now been verified by numerous studies and has been expanded to rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus, Graves' disease, generalized vitiligo and other human autoimmune diseases. In this paper, we discuss the association of PTPN22 with autoimmunity, the biochemistry of the PTPN22-encoded phosphatase, and the molecular mechanism(s) by which the disease-predisposing allele contributes to the development of human disease.
引用
收藏
页码：453 / 461
页数：9
相关论文
共 50 条
  • [21] Gaining insight into PTPN22 and autoimmunity
    Peter K Gregersen
    Nature Genetics, 2005, 37 : 1300 - 1302
  • [22] Gaining insight into PTPN22 and autoimmunity
    Gregersen, PK
    NATURE GENETICS, 2005, 37 (12) : 1300 - 1302
  • [23] Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity
    Orozco, Robin C.
    Marquardt, Kristi
    Mowen, Kerri
    Sherman, Linda A.
    JOURNAL OF IMMUNOLOGY, 2021, 207 (06): : 1662 - 1671
  • [24] Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity
    Orozco, Robin C.
    Marquardt, Kristi
    Pratumchai, Isaraphorn
    Shaikh, Anam Fatima
    Mowen, Kerri
    Domissy, Alain
    Teijaro, John R.
    Sherman, Linda A.
    PLOS PATHOGENS, 2024, 20 (03)
  • [25] Protein tyrosine phosphatase (PTPN22) R620W polymorphism and Tunisian pemphigus
    Kallel-Sellami, M.
    Mejri, K.
    Petit, E.
    Abida, O.
    Zitouni, M.
    Ben Ayed, M.
    Laadhar, L.
    Mokni, M.
    Fezaa, B.
    Mokhtar, I.
    Masmoudi, A.
    Turki, H.
    Ben Osmen, A.
    Kammoun, M. R.
    Gilbert, D.
    Joly, P.
    Masmoudi, H.
    Tron, F.
    Cornelis, F.
    Makni, S.
    TISSUE ANTIGENS, 2007, 69 (05): : 477 - 477
  • [26] The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
    Clarke, Fiona
    Purvis, Harriet A.
    Sanchez-Blanco, Cristina
    Gutierrez-Martinez, Enrique
    Cornish, Georgina H.
    Zamoyska, Rose
    Guermonprez, Pierre
    Cope, Andrew P.
    SCIENTIFIC REPORTS, 2018, 8
  • [27] Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice
    Georgia Fousteri
    Tatiana Jofra
    Roberta Di Fonte
    Nicola Gagliani
    Cristina Morsiani
    Angela Stabilini
    Manuela Battaglia
    Diabetologia, 2015, 58 : 1319 - 1328
  • [28] Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice
    Fousteri, Georgia
    Jofra, Tatiana
    Fonte, Roberta Di
    Gagliani, Nicola
    Morsiani, Cristina
    Stabilini, Angela
    Battaglia, Manuela
    DIABETOLOGIA, 2015, 58 (06) : 1319 - 1328
  • [29] The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
    Fiona Clarke
    Harriet A. Purvis
    Cristina Sanchez-Blanco
    Enrique Gutiérrez-Martinez
    Georgina H. Cornish
    Rose Zamoyska
    Pierre Guermonprez
    Andrew P. Cope
    Scientific Reports, 8
  • [30] The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) R620W Functional Polymorphism in Psoriasis
    Bin Huraib, Ghaleb
    Al Harthi, Fahad
    Arfin, Misbahul
    Rizvi, Sadaf
    Al-Asmari, Abdulrahaman
    CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS, 2018, 11
12345