Gaining insight into PTPN22 and autoimmunity

被引：0
|
作者：
Peter K Gregersen
机构：
[1] the Feinstein Institute for Medical Research,
[2] North Shore Long Island Jewish Health System,undefined
来源：
Nature Genetics | 2005年 / 37卷
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学科分类号：
摘要：
The protein tyrosine phosphatase PTPN22 (also called LYP) is the leading example of a genetic variant that confers risk of developing diverse human autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease and systemic lupus. A new study now shows that the PTPN22 risk-associated variant, Trp620, results in a gain of PTPN22 phosphatase activity in T cells, opening up new avenues for exploring disease mechanisms.
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页码：1300 / 1302
页数：2
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