Induction of tumor necrosis factor-α mRNA in the kidney of the mouse chronic hepatitis model

被引：1
|
作者：
Okamoto, T
Furuya, M
Yamakawa, T
Yamamura, K
Hino, O
机构：
[1] Japanese Fdn Canc Res, Inst Canc, Dept Expt Pathol, Toshima Ku, Tokyo 170, Japan
[2] Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 341, Japan
[3] Kumamoto Univ, Sch Med, Inst Mol Embryol & Genet, Kumamoto 862, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 76卷 / 01期
关键词：
transgenic mouse; interferon; tumor necrosis factor;
D O I：
10.1254/jjp.76.97
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1 beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.
引用
收藏
页码：97 / 99
页数：3
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