Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis

被引：16
|
作者：
Oka, A [1 ]
Takashima, S
Abe, M
Araki, R
Takeshita, K
机构：
[1] Tottori Univ, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 6838504, Japan
[2] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Kodaira, Tokyo 1878502, Japan
[3] Natl Inst Radiol Sci, Chiba 2638555, Japan
来源：
NEUROSCIENCE LETTERS | 2000年 / 292卷 / 03期
关键词：
DNA-dependent protein kinase; DNA-dependent protein kinase catalytic subunit; Ku; Ku80; human brains;
D O I：
10.1016/S0304-3940(00)01462-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku80 in developing human brain, both of which have been suggested to be involved in the repair of DNA double-strand break (DSB). Their expressions were well correlated, and the highest immunoreactivity was observed in post-mitotic immature neurons in the cerebral cortex as well as in progenitors in the periventricular germinal layer. The reactivity gradually decreased during development. Our results support the notion that DSB is generated during the ontogeny of the human central nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：167 / 170
页数：4
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