Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis

被引：16
|
作者：
Oka, A [1 ]
Takashima, S
Abe, M
Araki, R
Takeshita, K
机构：
[1] Tottori Univ, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 6838504, Japan
[2] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Kodaira, Tokyo 1878502, Japan
[3] Natl Inst Radiol Sci, Chiba 2638555, Japan
来源：
NEUROSCIENCE LETTERS | 2000年 / 292卷 / 03期
关键词：
DNA-dependent protein kinase; DNA-dependent protein kinase catalytic subunit; Ku; Ku80; human brains;
D O I：
10.1016/S0304-3940(00)01462-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku80 in developing human brain, both of which have been suggested to be involved in the repair of DNA double-strand break (DSB). Their expressions were well correlated, and the highest immunoreactivity was observed in post-mitotic immature neurons in the cerebral cortex as well as in progenitors in the periventricular germinal layer. The reactivity gradually decreased during development. Our results support the notion that DSB is generated during the ontogeny of the human central nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：167 / 170
页数：4
相关论文
共 50 条
  • [21] DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
    Lee, Ye -Rim
    Kang, Gi-Sue
    Oh, Taerim
    Jo, Hye-Ju
    Park, Hye-Joon
    Ahn, G. -One
    MOLECULES AND CELLS, 2023, 46 (04) : 200 - 205
  • [22] Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions
    Dip, R
    Naegeli, H
    BIOCHEMICAL JOURNAL, 2004, 381 : 165 - 174
  • [23] DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
    Hammarsten, O
    Chu, G
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 525 - 530
  • [24] DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair
    Li, Yong
    Li, Hang
    Peng, Wen
    He, Xin-Yun
    Huang, Min
    Qiu, Dong
    Xue, Ying-Bo
    Lu, Liang
    MOLECULAR MEDICINE REPORTS, 2015, 12 (01) : 1328 - 1334
  • [25] Expression of DNA-dependent protein kinase in human granulocytes
    Annahita SALLMYR
    Anna MILLER
    Aida GABDOULKHAKOVA
    Valentina SAFRONOVA
    Gunnel HENRIKSSON
    Anders BREDBERG
    Cell Research, 2004, 14 : 331 - 340
  • [26] DNA binding specificities of YPF1, a Drosophila homolog to the DNA binding subunit of human DNA-dependent protein kinase, Ku
    Jacoby, DB
    Wensink, PC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) : 16827 - 16832
  • [27] Expression of DNA-dependent protein kinase in human granulocytes
    Sallmyr, A
    Miller, A
    Gabdoulkhakova, A
    Safronova, V
    Henriksson, G
    Bredberg, A
    CELL RESEARCH, 2004, 14 (04) : 331 - 340
  • [28] Expression of DNA-dependent protein kinase in human granulocytes
    Annahita SALLMYR
    Anna MILLER
    Aida GABDOULKHAKOVA
    Valentina SAFRONOVA
    Gunnel HENRIKSSON
    Anders BREDBERG
    Cell Research, 2004, (04) : 331 - 340
  • [29] Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines
    Ihara, Makoto
    Ashizawa, Kiyoto
    Shichijo, Kazuko
    Kudo, Takashi
    JOURNAL OF RADIATION RESEARCH, 2019, 60 (02) : 171 - 177
  • [30] The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
    Calsou, P
    Frit, P
    Humbert, O
    Muller, C
    Chen, DJ
    Salles, B
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (12) : 7848 - 7856
12345