Cathelicidins Link the Endocrine and Immune Systems

被引:2
|
作者
Mayer, Matthew L. [1 ,2 ,3 ]
Hancock, Robert E. W. [1 ,2 ]
机构
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
[3] Univ British Columbia, Fac Med, Vancouver, BC V6T 1Z4, Canada
关键词
D O I
10.1016/j.chom.2010.04.002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Cathelicidin peptides play key roles in host responses to infection. Radek and colleagues (2010) demonstrate that the nicotinic acetylcholine system, activated during stress, suppresses production of mouse cathelicidin, increasing host susceptibility to the pathogen Staphylococcus aureus. This suggests a distinct way by which the endocrine system regulates innate immunity.
引用
收藏
页码:257 / 259
页数:3
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