IP3 receptors: Take four IP3 to open

被引：33

作者：

Taylor, Colin W. ^{[1
]}

Konieczny, Vera ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1PD, England

来源：

SCIENCE SIGNALING | 2016年 / 9卷 / 422期

基金：

英国惠康基金;

关键词：

INOSITOL TRISPHOSPHATE; CA2+; ION; CHANNELS;

D O I：

10.1126/scisignal.aaf6029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors are the channels responsible for Ca2+ release from the endoplasmic and sarcoplasmic reticulum. Research in Science Signaling by Alzayady et al. show that all four IP3-binding sites within the tetrameric IP3R must bind IP3 before the channel can open, which has important consequences for the distribution of both IP3 and IP3R activity within cells.

引用

页数：4

共 50 条

[41] IP3 receptors, IP3 transients, and nucleus-associated Ca2+ signals in cultured skeletal muscle
Jaimovich, E
Reyes, R
Liberona, JL
Powell, JA
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2000, 278 (05): : C998 - C1010
[42] Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity
Marchant, JS
Taylor, CW
CURRENT BIOLOGY, 1997, 7 (07) : 510 - 518
[43] CALCIUM AND IP3 REGULATE THE CALCIUM-CHANNEL FUNCTION OF THE HEPATIC IP3 RECEPTOR
DUFOUR, JF
TURNER, T
ARIAS, I
HEPATOLOGY, 1995, 22 (04) : 800 - 800
[44] Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP
Tovey, Stephen C.
Dedos, Skarlatos G.
Taylor, Emily J. A.
Church, Jarrod E.
Taylor, Colin W.
JOURNAL OF CELL BIOLOGY, 2008, 183 (02): : 297 - 311
[45] Targeted expression of IP3 sponge and IP3 DSRNA impaires sugar taste sensation in Drosophila
Usui-Aoki, K
Matsumoto, K
Koganezawa, M
Kohatsu, S
Isono, K
Matsubayashi, H
Yamamoto, MT
Ueda, R
Takahashi, K
Saigo, K
Mikoshiba, K
Yamamoto, D
JOURNAL OF NEUROGENETICS, 2005, 19 (3-4) : 123 - 141
[46] Measurement of intracellular IP3 concentration in living cells using the novel ratiometric IP3 biosensor
Nezu, A
Tanimura, A
Morita, T
Tojyo, Y
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 138P - 138P
[47] Interaction between IP3 receptors and BK channels in arterial smooth muscle: non-canonical IP3 signaling at work
Mujica, Patricio E.
Gonzalez, Francisco G.
JOURNAL OF GENERAL PHYSIOLOGY, 2011, 137 (05): : 473 - 477
[48] Inositol 1,4,5-trisphosphate (IP3) activation of IP3 receptors (IP3R) by ligand tuning of Ca2+ inhibition
Mak, DOD
McBride, S
Foskett, JK
BIOPHYSICAL JOURNAL, 1999, 76 (01) : A375 - A375
[49] Adenophostins: High-Affinity Agonists of IP3 Receptors
Rossi, Ana M.
Riley, Andrew M.
Potter, Barry V. L.
Taylor, Colin W.
STRUCTURE AND FUNCTION OF CALCIUM RELEASE CHANNELS, 2010, 66 : 209 - 233
[50] IP3 receptors and calcium signalling to the nucleus in muscle cells
Jaimovich, E
Liberona, JL
Carrasco, MA
Reyes, R
Powell, JA
JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 : 26S - 26S

← 1 2 3 4 5 →