IP3 receptors: Take four IP3 to open

被引：33

作者：

Taylor, Colin W. ^{[1
]}

Konieczny, Vera ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1PD, England

来源：

SCIENCE SIGNALING | 2016年 / 9卷 / 422期

基金：

英国惠康基金;

关键词：

INOSITOL TRISPHOSPHATE; CA2+; ION; CHANNELS;

D O I：

10.1126/scisignal.aaf6029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors are the channels responsible for Ca2+ release from the endoplasmic and sarcoplasmic reticulum. Research in Science Signaling by Alzayady et al. show that all four IP3-binding sites within the tetrameric IP3R must bind IP3 before the channel can open, which has important consequences for the distribution of both IP3 and IP3R activity within cells.

引用

页数：4

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