IP3 receptors: Take four IP3 to open

被引：33
|
作者：
Taylor, Colin W. [1 ]
Konieczny, Vera [1 ]
机构：
[1] Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1PD, England
来源：
SCIENCE SIGNALING | 2016年 / 9卷 / 422期
基金：
英国惠康基金;
关键词：
INOSITOL TRISPHOSPHATE; CA2+; ION; CHANNELS;
D O I：
10.1126/scisignal.aaf6029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors are the channels responsible for Ca2+ release from the endoplasmic and sarcoplasmic reticulum. Research in Science Signaling by Alzayady et al. show that all four IP3-binding sites within the tetrameric IP3R must bind IP3 before the channel can open, which has important consequences for the distribution of both IP3 and IP3R activity within cells.
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页数：4
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