Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice

被引:6
|
作者
Borsa, Baris A. [1 ]
Sudagidan, Mert [2 ]
Aldag, Mehmet E. [3 ]
Baris, Isik I. [4 ]
Acar, Elif E. [2 ]
Acuner, Cagatay [5 ]
Kavruk, Murat [6 ]
Ozalp, Veli C. [7 ]
机构
[1] Linkoping Univ, Dept Phys Chem & Biol IFM, Nucle Acid Technol Lab, SE-58183 Linkoping, Sweden
[2] Konya Food & Agr Univ, Kit Argem Res Ctr, TR-42080 Meram, Konya, Turkey
[3] Corlu State Hosp, Dept Med Microbiol, Tekirdag, Turkey
[4] Cakmak Erdem Hosp, Dept Pathol, Istanbul, Turkey
[5] Yeditepe Univ, Med Sch, Dept Med Microbiol, Istanbul, Turkey
[6] Turkish Stand Inst TSE, Test & Calibrat Ctr, TR-41400 Kocaeli, Turkey
[7] Atilim Univ, Med Sch, Dept Med Biol, TR-06830 Ankara, Turkey
来源
RSC MEDICINAL CHEMISTRY | 2021年 / 12卷 / 03期
关键词
D O I
10.1039/d0md00347f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antibiotic therapy comes with disturbances on human microbiota, resulting in changes of bacterial communities and thus leading to well-established health problems. In this study, we demonstrated that targeted teicoplanin administration maintains the faecal microbiota composition undisturbed in a mouse model while reaching therapeutic improvements for S. aureus infection.
引用
收藏
页码:380 / 383
页数:4
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