Evaluation of antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of Chrysanthemum fontanesii flowers and leaves extracts

被引：11
|
作者：
Amrani, Amel [1 ]
Mecheri, Amira [1 ]
Bensouici, Chawki [2 ]
Boubekri, Nassima [1 ]
Benaissa, Ouahiba [1 ]
Zama, Djamila [1 ]
Benayache, Fadila [1 ]
Benayache, Samir [1 ]
机构：
[1] Univ Freres Mentouri Constantine 1, Unite Rech Valorisat Ressources Nat Mol Bioact An, Route Ain El Bey, Constantine 25000, Algeria
[2] Ctr Rech Biotechnol CRBt, Constantine, Algeria
来源：
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY | 2019年 / 20卷
关键词：
Chrysanthemum fontanesii; Flavonols; Antioxidant; Photoprotective; Tyrosinase; alpha-Glucosidase; IN-VITRO ANTIOXIDANT; ALPHA-GLUCOSIDASE; TYROSINASE; AMYLASE; INHIBITORS; CAPACITY;
D O I：
10.1016/j.bcab.2019.101209
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This study was aimed to evaluate the antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of n-butanol extracts from leaves and flowers of Chrysanthemum fontanesii. beta-carotene-linoleic acid, Galvinoxyl radical (GOR), ABTS, hydroxyl radical, reducing power, CUPRAC, O-phenanthroline and metal chelating assays were used to evaluate antioxidant capacity of the extracts. The extracts showed good antioxidant activity and were a good source of phenolics and flavonoids. The enzyme inhibitory activity of the extracts was investigated against key enzymes involved in neurodegenerative [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE], type 2 diabetes (alpha-glucosidase) and skin (tyrosinase) disorders. In the cholinesterase inhibitory assays, the extracts of leaves and flowers exhibited weak activity against AChE and BChE. n-butanol extracts from leaves and flowers displayed high inhibitory activity against alpha-glucosidase, showing potential properties against type 2 diabetes. Whereas for anti-tyrosinase activity, only flowers extract showed good inhibitory activity. Furthermore the leaves and flowers extracts showed high photoprotective activity with the sun protection factor (SPF) value: 38.96 +/- 0.26 and 38.66 +/- 0.68, respectively. Our study on C. fontanesii open new perspectives for developing novel health-promoting agents by pharmaceutical, cosmetics and food industries.
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页数：7
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