Effect of NlpE Overproduction on Multidrug Resistance in Escherichia coli

被引：35
|
作者：
Nishino, Kunihiko [1 ,3 ]
Yamasaki, Seiji [1 ,2 ,4 ]
Hayashi-Nishino, Mitsuko [2 ]
Yamaguchi, Akihito [2 ,4 ]
机构：
[1] Osaka Univ, Lab Microbiol & Infect Dis, Inst Sci & Ind Res, Osaka 5670047, Japan
[2] Osaka Univ, Dept Cell Membrane Biol, Inst Sci & Ind Res, Osaka 5670047, Japan
[3] Japan Sci & Technol Corp, PRESTO, Tokyo 1020075, Japan
[4] Osaka Univ, Sch Pharmaceut Sci, Osaka 5650871, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
EXTRACYTOPLASMIC STRESS; OUTER-MEMBRANE; EFFLUX PUMPS; GENES; TRANSPORTERS; SALMONELLA; EXPRESSION; PATHWAY; TYPHIMURIUM; TOLERANCE;
D O I：
10.1128/AAC.01677-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.
引用
收藏
页码：2239 / 2243
页数：5
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