Catalyst-Free, Visible-Light Promoted One-Pot Synthesis of Spirooxindole-Pyran Derivatives in Aqueous Ethyl Lactate

被引：172

作者：

Zhang, Mo ^{[1
]}

Fu, Qiu-Yang ^{[1
]}

Gao, Ge ^{[1
]}

He, He-Ye ^{[1
]}

Zhang, Ying ^{[1
]}

Wu, Yin-Su ^{[1
]}

Zhang, Zhan-Hui ^{[1
]}

机构：

[1] Hebei Normal Univ, Coll Chem & Mat Sci, 20 Rd East 2nd Ring South, Shijiazhuang 050024, Peoples R China

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2017年 / 5卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Visible-light; Catalyst-free; Spirooxindoles; Multicomponent reaction; Heterocyclic compounds; Ethyl lactate; CROSS-COUPLING REACTIONS; DEEP EUTECTIC SOLVENTS; 3-COMPONENT SYNTHESIS; 4-COMPONENT SYNTHESIS; SUPPORTED MOLYBDENUM; BOND-CLEAVAGE; EFFICIENT; DIVERSITY; DIHYDROPYRIDINES; PHOTOCATALYSIS;

D O I：

10.1021/acssuschemeng.7b01102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient, eco-friendly protocol has been developed for synthesis of spirooxindole-pyran derivatives via one-pot, three-component reaction of isatins, malononitrile, and enolizable C-H activated compounds (2-hydroxynaphthalene 1,4-dione, 4-hydroxycoumarine and dimedone) under visible-light irradiation in water-ethyl lactate at room temperature. The reported approach shows significant advantages such as a high yield, mild and clean reaction conditions, the application of clean visible light as a source of energy, the absence of catalyst, the use of ethyl lactate/water as an environmentally friendly solvent, a one-pot multicomponent reaction at room temperature, no chromatographic separation, and applicability for large-scale synthesis.

引用

页码：6175 / 6182

页数：8

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