The First Total Synthesis of Pectinolides D and E and Total Synthesis of Pectinolides A and C

被引：5
|
作者：
Sabitha, Gowravaram [1 ]
AnkiReddy, Praveen [1 ]
Das, Sukant Kishore [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 03期
关键词：
pectinolides; first synthesis; aldehyde-alkyne coupling; Noyori reduction; Still-Genari cis-olefination; STEREOSELECTIVE TOTAL-SYNTHESIS; HYPTIS-PECTINATA; D-MANNITOL; LACTONE;
D O I：
10.1055/s-0034-1378912
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first total synthesis of pectinolides D and E and total synthesis of pectinolides A and C was achieved from a hitherto unknown common key building block prepared from readily available D-mannitol. Key reactions involved in the synthesis are Red-Al reduction of an epoxy alcohol, enantioselective Noyori reduction of ynones, aldehyde-alkyne coupling, and Still-Genari cis-olefination.
引用
收藏
页码：330 / 342
页数：13
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