UCB 62045 - Pharmacology of a novel, dual-function anti-inflammatory agent with histamine type 1 receptor antagonist and 5-lipoxygenase inhibitor activity

被引：4
|
作者：
Selig, WM [1 ]
Bayless, L [1 ]
Libertine, L [1 ]
Eckman, JB [1 ]
Wypij, DM [1 ]
Wels, BF [1 ]
Eckert, M [1 ]
Young, MA [1 ]
Nicolas, JM [1 ]
Scannell, RT [1 ]
Ellis, JL [1 ]
机构：
[1] UCB Res Inc, Pharmacol, Cambridge, MA 02139 USA
来源：
CHEST | 2003年 / 123卷 / 03期
关键词：
D O I：
10.1378/chest.123.3_suppl.371S
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：371S / 371S
页数：1
相关论文
共 37 条
  • [31] Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats
    Kondo, Mitsuhiro
    Tahara, Atsuo
    Hayashi, Kazumi
    Abe, Masaki
    Inami, Hiroshi
    Ishikawa, Takeshi
    Ito, Hiroyuki
    Tomura, Yuichi
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2014, 387 (10) : 909 - 919
  • [32] Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats
    Mitsuhiro Kondo
    Atsuo Tahara
    Kazumi Hayashi
    Masaki Abe
    Hiroshi Inami
    Takeshi Ishikawa
    Hiroyuki Ito
    Yuichi Tomura
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, 387 : 909 - 919
  • [33] The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis
    Birker-Robaczewska, Magdalena
    Boucher, Maxime
    Ranieri, Giulia
    Poirey, Sylvie
    Studer, Rolf
    Freti, Diego
    Schnoebelen, Marie
    Froidevaux, Sylvie
    Morrison, Keith
    Wyss, Conrad
    Scherer, Jeremy
    Lescop, Cyrille
    Brotschi, Christine
    Bolli, Martin H.
    Kramberg, Markus
    Di Stefano, Simone
    Rey, Markus
    Iglarz, Marc
    Delahaye, Stephane
    Vezzali, Enrico
    Sieber, Patrick
    Schafer, Anny
    Caimi, Silvia L.
    Hesse, Christina
    Nayler, Oliver
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2025, 392 (03):
  • [34] The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase
    Koeberle, Andreas
    Rossi, Antonietta
    Zettl, Heiko
    Pergola, Carlo
    Dehm, Friederike
    Bauer, Julia
    Greiner, Christine
    Reckel, Sina
    Hoernig, Christina
    Northoff, Hinnak
    Bernhard, Frank
    Doetsch, Volker
    Sautebin, Lidia
    Schubert-Zsilavecz, Manfred
    Werz, Oliver
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 332 (03): : 840 - 848
  • [35] Discovery of 5-(3,4-dihydroxybenzylidene)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione as a novel and effective cardioprotective agent via dual anti-inflammatory and anti-oxidative activities
    Shi, Yang-Yang
    Wei, Bo
    Zhou, Jing
    Yin, Zhi-Li
    Zhao, Fei
    Peng, Ya-Jie
    Yu, Qing-Wen
    Wang, Xin-Lu
    Chen, Ya-Jing
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 244
  • [36] Dual COX-2 and 15-LOX inhibition study of novel 4-arylidine-2-mercapto-1-phenyl-1H-imidazolidin-5(4H)-ones: Design, synthesis, docking, and anti-inflammatory activity
    Osman, Nermine A.
    Soltan, Mostafa K.
    Rezq, Samar
    Flaherty, Joseph
    Romero, Damian G.
    Abdelkhalek, Ahmed S.
    ARCHIV DER PHARMAZIE, 2024, 357 (05)
  • [37] Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): From dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers
    Campiani, G
    Fiorini, I
    DeFilippis, MP
    Ciani, SM
    Garofalo, A
    Nacci, V
    Giorgi, G
    Sega, A
    Botta, M
    Chiarini, A
    Budriesi, R
    Bruni, G
    Romeo, MR
    Manzoni, C
    Mennini, T
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2922 - 2938
1234