UCB 62045 - Pharmacology of a novel, dual-function anti-inflammatory agent with histamine type 1 receptor antagonist and 5-lipoxygenase inhibitor activity

被引：4
|
作者：
Selig, WM [1 ]
Bayless, L [1 ]
Libertine, L [1 ]
Eckman, JB [1 ]
Wypij, DM [1 ]
Wels, BF [1 ]
Eckert, M [1 ]
Young, MA [1 ]
Nicolas, JM [1 ]
Scannell, RT [1 ]
Ellis, JL [1 ]
机构：
[1] UCB Res Inc, Pharmacol, Cambridge, MA 02139 USA
来源：
CHEST | 2003年 / 123卷 / 03期
关键词：
D O I：
10.1378/chest.123.3_suppl.371S
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：371S / 371S
页数：1
相关论文
共 37 条
  • [21] Anti-allergic, anti-asthmatic and anti-inflammatory effects of an oxazolidinone hydroxamic acid derivative (PH-251)-A novel dual inhibitor of 5-lipoxygenase and mast cell degranulation
    Ezeamuzie, Charles, I
    Rao, Muddanna S.
    El-Hashim, Ahmed Z.
    Philip, Elizabeth
    Phillips, Oludotun A.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 105
  • [22] Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity
    Chowdhury, Morshed A.
    Abdellatif, Khaled R. A.
    Dong, Ying
    Das, Dipankar
    Suresh, Mavanur R.
    Knaus, Edward E.
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (06) : 1525 - 1529
  • [23] Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion
    Kushida, I
    Ichikawa, M
    Asakawa, N
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (01) : 258 - 266
  • [24] Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin
    Schaible, Anja M.
    Traber, Heidi
    Temml, Veronika
    Noha, Stefan M.
    Filosa, Rosanna
    Peduto, Antonella
    Weinigel, Christina
    Barz, Dagmar
    Schuster, Daniela
    Werz, Oliver
    BIOCHEMICAL PHARMACOLOGY, 2013, 86 (04) : 476 - 486
  • [25] STRUCTURE-ACTIVITY-RELATIONSHIPS OF WAY-125,007, A DUAL-ACTING LEUKOTRIENE-D4 RECEPTOR ANTAGONIST AND 5-LIPOXYGENASE (5-LO) TRANSLOCATION INHIBITOR
    KREFT, AF
    KUBRAK, DM
    BANKER, AL
    NELSON, JA
    SHAH, US
    FAILLI, AA
    BLEYMAN, O
    MUSSER, JH
    CARLSON, RP
    HARTMAN, DA
    HOWELL, D
    HOWELL, R
    FIELDING, LE
    GRAY, W
    GRIME, D
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 106 - MEDI
  • [26] Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
    Yu, Gang
    Chowdhury, Morshed A.
    Abdellatif, Khaled R. A.
    Dong, Ying
    Rao, P. N. Praveen
    Das, Dipankar
    Velazquez, Carlos A.
    Suresh, Mavanur R.
    Knaus, Edward E.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (03) : 896 - 902
  • [27] Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity
    Fettel, Jasmin
    Kuehn, Benjamin
    Guillen, Nathalie A.
    Sueruen, Duran
    Peters, Marcus
    Bauer, Rebekka
    Angioni, Carlo
    Geisslinger, Gerd
    Schnuetgen, Frank
    zu Heringdorf, Dagmar Meyer
    Werz, Oliver
    Meybohm, Patrick
    Zacharowski, Kai
    Steinhilber, Dieter
    Roos, Jessica
    Maier, Thorsten J.
    FASEB JOURNAL, 2019, 33 (02): : 1711 - 1726
  • [28] The inhibitory effect of TMK688, a novel anti-allergic drug having both 5-lipoxygenase inhibitory activity and anti-histamine activity, against bronchoconstriction, leukotriene production and inflammatory cell infiltration in sensitized guinea pigs
    Tohda, Y
    Nakajima, S
    Shizawa, T
    Maeda, K
    Ohmori, S
    Satoh, H
    Ishii, T
    Kamitani, T
    CLINICAL AND EXPERIMENTAL ALLERGY, 1997, 27 (01): : 110 - 118
  • [29] Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl) acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
    Chowdhury, Morshed Alam
    Abdellatif, Khaled R. A.
    Dong, Ying
    Rahman, Moshfiqur
    Das, Dipankar
    Suresh, Mavanur R.
    Knaus, Edward E.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 584 - 588
  • [30] Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
    Chowdhury, Morshed A.
    Abdellatif, Khaled R. A.
    Dong, Ying
    Das, Dipankar
    Yu, Gang
    Velazquez, Carlos A.
    Suresh, Mavanur R.
    Knaus, Edward E.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (24) : 6855 - 6861
1234