Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

被引：39
|
作者：
Takeuchi, Y [1 ]
Azuma, K [1 ]
Takakura, K [1 ]
Abe, H [1 ]
Harayama, T [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan
来源：
CHEMICAL COMMUNICATIONS | 2000年 / 17期
关键词：
D O I：
10.1039/b005028h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((+/-)-3) using baker's yeast.
引用
收藏
页码：1643 / 1644
页数：2
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