Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

被引：39

作者：

Takeuchi, Y ^{[1
]}

Azuma, K ^{[1
]}

Takakura, K ^{[1
]}

Abe, H ^{[1
]}

Harayama, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 17期

关键词：

D O I：

10.1039/b005028h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((+/-)-3) using baker's yeast.

引用

页码：1643 / 1644

页数：2

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