Synthesis of D/L-febrifugine and D/L-isofebrifugine

被引：1
|
作者：
Takeuchi, Y [1 ]
Hattori, M [1 ]
Abe, H [1 ]
Harayama, T [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan
来源：
SYNTHESIS-STUTTGART | 1999年 / 10期
关键词：
Claisen rearrangement; stereoselective reduction; febrifugine; isofebrifugine; antimalarial agent;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Racemic compounds (1 and 2) of the antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized using an unusual Claisen rearrangement of allyl enol ether 6 and the stereoselective reduction of 2-allylpiperid-3-one 8. This method is widely applicable to the synthesis of febirifugine derivatives.
引用
收藏
页码：1814 / 1818
页数：5
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