Discovery of novel linkers, payloads, and antibody-drug conjugates for the treatment of cancer

被引：0
|
作者：
O'Donnell, Christopher [1 ]
机构：
[1] Pfizer Inc, Groton, CT 06340 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 250卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
259
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Lysosomal-Cleavable Peptide Linkers in Antibody-Drug Conjugates
    Balamkundu, Seetharamsing
    Liu, Chuan-Fa
    [J]. BIOMEDICINES, 2023, 11 (11)
  • [42] Development and properties of β-glucuronide linkers for monoclonal antibody-drug conjugates
    Jeffrey, SC
    Andreyka, JB
    Bernhardt, SX
    Kissler, KM
    Kline, T
    Lenox, JS
    Moser, RF
    Nguyen, MT
    Okeley, NM
    Stone, IJ
    Zhang, XQ
    Senter, PD
    [J]. BIOCONJUGATE CHEMISTRY, 2006, 17 (03) : 831 - 840
  • [43] Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates
    Thomas, Joshua D.
    Yurkovetskiy, Aleksandr, V
    Yin, Mao
    Bodyak, Natalya D.
    Gumerov, Dmitry R.
    Tang, Shuyi
    Kelleher, Eoin
    Jones, Brian D.
    Protopopova, Marina
    Qin, LiuLiang
    Uttard, Alex
    Demady, Damon R.
    Lowinger, Timothy B.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 72
  • [44] Discovery of the novel, homogeneous payload platform dolasynthen for antibody-drug conjugates
    Kozytska, M.
    Yurkovetskiy, A.
    Yin, M.
    Bodyak, N.
    Conlon, P.
    Du, B.
    Stevenson, C.
    Gumerov, D.
    Nazzaro, M.
    Lee, D.
    Lee, W.
    Qin, L.
    Catcott, K.
    Demady, D.
    Collins, S.
    Xu, J.
    Duvall, J.
    Damelin, M.
    Toader, D.
    Lowinger, T.
    [J]. EUROPEAN JOURNAL OF CANCER, 2018, 103 : E92 - E92
  • [45] Development of novel antibody-drug conjugates
    Takahashi, Shunji
    [J]. CANCER SCIENCE, 2021, 112 : 1026 - 1026
  • [46] Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
    Grier, Katja E.
    Hansen, Anders H.
    Haxvig, Christina S.
    Li, Xin
    Krigslund, Oliver
    Behrendt, Niels
    Engelholm, Lars H.
    Rossi, Fabio
    Sousa, Bebiana C.
    Harradence, Grant J.
    Camper, Nicolas
    Qvortrup, Katrine M.
    [J]. CHEMICAL COMMUNICATIONS, 2023, 59 (47) : 7240 - 7242
  • [47] Antibody-drug conjugates with uncleavable linkers for the treatment of non-hodgkin lymphoma.
    Polson, Andrew G.
    Lark, Suzarma C.
    Du, Changchun
    Eaton, Dan
    Elkins, Kristi
    Fuji, Rtina N.
    Go, Mary Ann
    Gray, Alane
    Januario, Tom
    Koeppen, Hartmut
    Lau, Jeffery
    Leach, Will
    McDorman, Elena
    McKeever, Kathleen
    Prabhu, Saileta
    Scales, Suzie J.
    Slaga, Dionysos
    Spencer, Susan
    Williams, Marna
    Xie, David
    Yu, Shang-Fan
    Zheng, Bing
    Ebens, Allen
    [J]. BLOOD, 2007, 110 (11) : 162A - 162A
  • [48] Natural Products as Exquisitely Potent Cytotoxic Payloads for Antibody-Drug Conjugates
    Gromek, Samantha M.
    Balunas, Marcy J.
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2014, 14 (24) : 2822 - 2834
  • [49] Antibody-Drug Conjugates for Breast Cancer
    Marme, Frederik
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (1-2) : 26 - 36
  • [50] Antibody-Drug Conjugates for Cancer Therapy
    Hafeez, Umbreen
    Parakh, Sagun
    Gan, Hui K.
    Scott, Andrew M.
    [J]. MOLECULES, 2020, 25 (20):
12345