Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

被引：4

作者：

Grier, Katja E. ^{[1
]}

Hansen, Anders H. ^{[1
]}

Haxvig, Christina S. ^{[1
]}

Li, Xin ^{[2
]}

Krigslund, Oliver ^{[3
]}

Behrendt, Niels ^{[3
]}

Engelholm, Lars H. ^{[3
]}

Rossi, Fabio ^{[4
]}

Sousa, Bebiana C. ^{[4
]}

Harradence, Grant J. ^{[4
]}

Camper, Nicolas ^{[4
]}

Qvortrup, Katrine M. ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

[2] Univ Copenhagen UCPH, Rigshospitalet Biotech Res & Innovat Ctr BRIC, Finsen Lab, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark

[3] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark

[4] Abzena Ltd, Babraham Res Campus, Babraham CB22 3AT, England

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 47期

关键词：

D O I：

10.1039/d3cc01596c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

引用

页码：7240 / 7242

页数：3

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