NOD-like receptor (NLR) signaling beyond the inflammasome

被引：95
|
作者：
Shaw, Patrick J. [1 ]
Lamkanfi, Mohamed [2 ,3 ]
Kanneganti, Thirumala-Devi [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium
[3] VIB, Dept Med Prot Res, Ghent, Belgium
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期
关键词：
Inflammasome; Innate immunity; NLR; NF-KAPPA-B; CUTTING EDGE; INNATE; EXPRESSION; MONARCH-1; PROTEIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; MUTATIONS;
D O I：
10.1002/eji.200940211
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
引用
收藏
页码：624 / 627
页数：4
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