NOD-like receptor (NLR) signaling beyond the inflammasome

被引：95
|
作者：
Shaw, Patrick J. [1 ]
Lamkanfi, Mohamed [2 ,3 ]
Kanneganti, Thirumala-Devi [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium
[3] VIB, Dept Med Prot Res, Ghent, Belgium
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期
关键词：
Inflammasome; Innate immunity; NLR; NF-KAPPA-B; CUTTING EDGE; INNATE; EXPRESSION; MONARCH-1; PROTEIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; MUTATIONS;
D O I：
10.1002/eji.200940211
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
引用
收藏
页码：624 / 627
页数：4
相关论文
共 50 条
  • [31] The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases
    Xiaolin Xu
    Xianli Wu
    Gengyu Yue
    Qimin An
    Jun Lou
    Xiaoxu Yang
    Zhe Jin
    Jianhong Ding
    Yanxia Hu
    Qian Du
    Jingyu Xu
    Rui Xie
    Molecular and Cellular Biochemistry, 2023, 478 : 1397 - 1410
  • [32] The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson' disease
    Wang, Jing
    Zhang, Xiao-Na
    Fang, Jin-Ni
    Hua, Fei-Fei
    Han, Jing-Yang
    Yuan, Zeng-Qiang
    Xie, An-Mu
    NEURAL REGENERATION RESEARCH, 2022, 17 (04) : 898 - +
  • [33] Nod-Like Receptor Protein 1 Inflammasome Mediates Neuron Injury under High Glucose
    Xian-Fang Meng
    Xiao-Lan Wang
    Xiu-Juan Tian
    Zhi-Hua Yang
    Guang-Pin Chu
    Jing Zhang
    Man Li
    Jing Shi
    Chun Zhang
    Molecular Neurobiology, 2014, 49 : 673 - 684
  • [34] Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)
    Sahoo, Bikash Ranjan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 161 : 1602 - 1617
  • [35] Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism
    Gomes Torres, Ana Claudia M. B.
    Leite, Neiva
    Tureck, Luciane Viater
    Rodrigues de Souza, Ricardo Lehtonen
    Kapp Titski, Ana Claudia
    Milano-Gai, Gerusa Eisfeld
    Lazarotto, Leilane
    da Silva, Larissa Rosa
    Furtado-Alle, Lupe
    GENE, 2019, 685 : 211 - 221
  • [36] Structural mechanism for autoinhibition of a NOD-like receptor
    Science Foundation in China, 2013, (02) : 12 - 12
  • [37] REGULATION OF NOD-LIKE RECEPTORS AND INFLAMMASOME ACTIVATION IN CEREBRAL ENDOTHELIAL CELLS
    Krizbai, I. A.
    Nyul-Toth, A.
    Molnar, J.
    Fazakas, C.
    Hasko, J.
    Wilhelm, I.
    Nagyoszi, P.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 : 259 - 259
  • [38] The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease
    Jing Wang
    Xiao-Na Zhang
    Jin-Ni Fang
    Fei-Fei Hua
    Jing-Yang Han
    Zeng-Qiang Yuan
    An-Mu Xie
    Neural Regeneration Research, 2022, 17 (04) : 898 - 904
  • [39] Regulation of NOD-like receptors and inflammasome activation in cerebral endothelial cells
    Nagyoszi, Peter
    Nyul-Toth, Adam
    Fazakas, Csilla
    Wilhelm, Imola
    Kozma, Mihaly
    Molnar, Judit
    Hasko, Janos
    Krizbai, Istvan A.
    JOURNAL OF NEUROCHEMISTRY, 2015, 135 (03) : 551 - 564
  • [40] Targeting the NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome to Improve Healing of Diabetic Wounds
    Cavalcante-Silva, Jacqueline
    Koh, Timothy J.
    ADVANCES IN WOUND CARE, 2023, 12 (11) : 644 - 656
12345