NOD-like receptor (NLR) signaling beyond the inflammasome

被引：95

作者：

Shaw, Patrick J. ^{[1
]}

Lamkanfi, Mohamed ^{[2
,3
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

[3] VIB, Dept Med Prot Res, Ghent, Belgium

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期

关键词：

Inflammasome; Innate immunity; NLR; NF-KAPPA-B; CUTTING EDGE; INNATE; EXPRESSION; MONARCH-1; PROTEIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; MUTATIONS;

D O I：

10.1002/eji.200940211

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.

引用

页码：624 / 627

页数：4

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