BDNF controls object recognition memory reconsolidation

被引：44
|
作者：
Radiske, Andressa [1 ]
Rossato, Janine I. [1 ]
Gonzalez, Maria Carolina [1 ]
Kohler, Cristiano A. [1 ]
Bevilaqua, Lia R. [1 ]
Cammarota, Martin [1 ]
机构：
[1] Univ Fed Rio Grande do Norte, Brain Inst, Memory Res Lab, Av Nascimento Castro 2155, BR-59056450 Natal, RN, Brazil
来源：
NEUROBIOLOGY OF LEARNING AND MEMORY | 2017年 / 142卷
关键词：
Anisomycin; alpha-amanitin; Muscimol; Novelty; Retrieval; MEDIAL PREFRONTAL CORTEX; LONG-TERM-MEMORY; SPATIAL MEMORY; PROTEIN-SYNTHESIS; TRANSLATION MACHINERY; DORSAL HIPPOCAMPUS; PERIRHINAL CORTEX; MAMMALIAN TARGET; CONSOLIDATION; RETRIEVAL;
D O I：
10.1016/j.nlm.2017.02.018
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA(1) impairs updating of the reactivated recognition memory trace. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：79 / 84
页数：6
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