Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

被引：105

作者：

Pruksakorn, Patamaporn ^{[1
]}

Arai, Masayoshi ^{[1
]}

Kotoku, Naoyuki ^{[1
]}

Vilcheze, Catherine ^{[2
]}

Baughn, Anthony D. ^{[2
]}

Moodley, Prashini ^{[3
]}

Jacobs, William R., Jr. ^{[2
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Albert Einstein Coll Med, Howard Hughes Med Inst, Price Translat Res Ctr, Bronx, NY 10461 USA

[3] Univ KwaZulu Natal, Nelson R Mandela Sch Med, ZA-4013 Congella Durban, South Africa

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期

关键词：

Trichoderin; Trichoderma sp; Aminolipopeptide; Anti-mycobacterial activity; Dormant; Tuberculosis; DEPLETION-INDUCED DORMANCY; NONREPLICATING PERSISTENCE; PEPTIDE ANTIBIOTICS; MYCOGONE-ROSEA; TUBERCULOSIS; POLYSPORUM;

D O I：

10.1016/j.bmcl.2010.04.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 mu g/mL. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3658 / 3663

页数：6

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