Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

被引：105
|
作者：
Pruksakorn, Patamaporn [1 ]
Arai, Masayoshi [1 ]
Kotoku, Naoyuki [1 ]
Vilcheze, Catherine [2 ]
Baughn, Anthony D. [2 ]
Moodley, Prashini [3 ]
Jacobs, William R., Jr. [2 ]
Kobayashi, Motomasa [1 ]
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Albert Einstein Coll Med, Howard Hughes Med Inst, Price Translat Res Ctr, Bronx, NY 10461 USA
[3] Univ KwaZulu Natal, Nelson R Mandela Sch Med, ZA-4013 Congella Durban, South Africa
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期
关键词：
Trichoderin; Trichoderma sp; Aminolipopeptide; Anti-mycobacterial activity; Dormant; Tuberculosis; DEPLETION-INDUCED DORMANCY; NONREPLICATING PERSISTENCE; PEPTIDE ANTIBIOTICS; MYCOGONE-ROSEA; TUBERCULOSIS; POLYSPORUM;
D O I：
10.1016/j.bmcl.2010.04.100
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 mu g/mL. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3658 / 3663
页数：6
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