Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

被引：348

作者：

Devaraj, Neal K. ^{[1
]}

Hilderbrand, Scott ^{[1
]}

Upadhyay, Rabi ^{[1
]}

Mazitschek, Ralph ^{[1
]}

Weissleder, Ralph ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Richard B Simches Res Ctr, Boston, MA 02114 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 16期

关键词：

bioorthogonal; reactions; cycloaddition; fluorogenic tags; imaging; tetrazine; COPPER(I)-CATALYZED AZIDE-ALKYNE; CLICK CHEMISTRY; STAUDINGER LIGATION; FLUORESCENT TAXOIDS; CANCER-CELLS; COPPER-FREE; CYCLOADDITION; SYSTEMS; ABSENCE; DYE;

D O I：

10.1002/anie.200906120

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Glowing tags: A series of activatable ("urn-on") tetrazine-conjugated fluorescent probes was developed, which react rapidly in an inverse-electron-demand [4+2] cycloaddition with strained dienophiles such as trans-cyclooctene, thereby strongly increasing the fluorescence intensity (see picture), The novel turn-on probes were applied for intracellular livecell imaging of a microtubuli-binding trans-cyclooctene modified taxol, © 2010 Wiley-VCH Verlag GmbH & Co. KGaA,.

引用

页码：2869 / 2872

页数：4

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