Genes for mitochondria in arterial hypertension and left ventricular hypertrophy

被引：2
|
作者：
Buikin, S. V. [1 ]
Golubenko, M. V. [1 ]
Puzyrev, V. P. [1 ,2 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Inst Med Genet, Tomsk 634050, Russia
[2] Siberian State Med Univ, Russian Minist Hlth & Social Dev, Tomsk 634050, Russia
来源：
MOLECULAR BIOLOGY | 2010年 / 44卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
arterial hypertension; left ventricular hypertrophy; analysis of association; common disease; mtDNA; POLG1; DNA POLYMERASE; HAPLOGROUPS; MTDNA; ORGANIZATION; METABOLISM; SELECTION; EVOLUTION; HEART;
D O I：
10.1134/S0026893310010048
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polymorphic markers were studied in mitochondrial DNA and the nuclear POLG1 gene, coding for mitochondrial DNA polymerase gamma. Their frequencies were compared between healthy individuals and patients with arterial hypertension, as well as between patients with and without left ventricular hypertrophy. The healthy group was found not to be clearly dominated by the C allele of MspI polymorphism in POLG1. Mitochondrial haplogroup H was more frequent (OR = 0.42; 95%CI 0.17-0.98; p = 0.043) in patients without left ventricular hypertrophy than in patients having this complication. Haplogroup T was more often detected in patients with left ventricular hypertrophy (OR = 6.16; 95%CI 1.17-9.74; p = 0.018). This result suggests the implication of mitochondrial DNA in hereditary susceptibility to cardiovascular diseases.
引用
收藏
页码：23 / 27
页数：5
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