Genes for mitochondria in arterial hypertension and left ventricular hypertrophy

被引：2

作者：

Buikin, S. V. ^{[1
]}

Golubenko, M. V. ^{[1
]}

Puzyrev, V. P. ^{[1
,2
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Med Genet, Tomsk 634050, Russia

[2] Siberian State Med Univ, Russian Minist Hlth & Social Dev, Tomsk 634050, Russia

来源：

MOLECULAR BIOLOGY | 2010年 / 44卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

arterial hypertension; left ventricular hypertrophy; analysis of association; common disease; mtDNA; POLG1; DNA POLYMERASE; HAPLOGROUPS; MTDNA; ORGANIZATION; METABOLISM; SELECTION; EVOLUTION; HEART;

D O I：

10.1134/S0026893310010048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polymorphic markers were studied in mitochondrial DNA and the nuclear POLG1 gene, coding for mitochondrial DNA polymerase gamma. Their frequencies were compared between healthy individuals and patients with arterial hypertension, as well as between patients with and without left ventricular hypertrophy. The healthy group was found not to be clearly dominated by the C allele of MspI polymorphism in POLG1. Mitochondrial haplogroup H was more frequent (OR = 0.42; 95%CI 0.17-0.98; p = 0.043) in patients without left ventricular hypertrophy than in patients having this complication. Haplogroup T was more often detected in patients with left ventricular hypertrophy (OR = 6.16; 95%CI 1.17-9.74; p = 0.018). This result suggests the implication of mitochondrial DNA in hereditary susceptibility to cardiovascular diseases.

引用

页码：23 / 27

页数：5

共 50 条

[21] Hypertension and left ventricular hypertrophy
Aronow, Wilbert S.
ANNALS OF TRANSLATIONAL MEDICINE, 2017, 5 (15)
[22] Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension
Litwin, Mieczyslaw
Niemirska, Anna
Sladowska, Joanna
Antoniewicz, Jolanta
Daszkowska, Joanna
Wierzbicka, Aldona
Wawer, Zbigniew T.
Grenda, Ryszard
PEDIATRIC NEPHROLOGY, 2006, 21 (06) : 811 - 819
[23] Economic benefits of left ventricular hypertrophy regression in patients with arterial hypertension
Tarlovskaya, E. I.
Maksimchuk, N. S.
Malchicova, S. V.
Avksentieva, M. V.
Sapozhnikova, I. E.
Balandina, Y. A.
RATIONAL PHARMACOTHERAPY IN CARDIOLOGY, 2011, 7 (05) : 543 - 548
[24] Five years prognosis of patients with arterial hypertension and left ventricular hypertrophy
Djordjevic, Dragan
Tasic, Ivan
Stamenkovic, Bojana
Lovic, Milan
Lovic, Branko
Lovic, Dragan
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 137 : S77 - S77
[25] PATHOGENESIS OF LEFT-VENTRICULAR HYPERTROPHY IN PATIENTS WITH ARTERIAL-HYPERTENSION
DYADYK, AI
BAGRIY, AE
LEBED, IA
YAROVAYA, NF
KARDIOLOGIYA, 1995, 35 (01) : 59 - 63
[26] ADHERENCE TO ANTIHYPERTENSIVE MEDICATION AND LEFT VENTRICULAR HYPERTROPHY IN RESISTANT ARTERIAL HYPERTENSION
Kamasova, M.
Vaclavik, J.
Vaclavik, T.
Kocianova, E.
Jarkovsky, J.
Benesova, K.
Jelinek, L.
Taborsky, M.
JOURNAL OF HYPERTENSION, 2019, 37 : E315 - E315
[27] ARTERIAL STIFFNESS AND LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH WHITE COAT HYPERTENSION
Sole, Ricardo Cabrera
Lucas, Caridad Turpin
Luepke, Erick
JOURNAL OF HYPERTENSION, 2024, 42
[28] Obesity and diabetes mellitus and left ventricular hypertrophy in patients with arterial hypertension
Sedkowska, Agnieszka
Gawron-Kiszka, Magdalena
Tomaszewski, Maciej
Kowalczyk, Jacek
Streb, Witold
Markowicz-Pawlus, Ewa
Obrebska, Jadwiga
Kalarus, Zbigniew
Zukowska-Szczechowska, Ewa
ARTERIAL HYPERTENSION, 2011, 15 (02): : 93 - 101
[29] The Relationship of Carotid Arterial Stiffness and Left Ventricular Concentric Hypertrophy in Hypertension
Jaroch, Joanna
Loboz-Grudzien, Krystyna
Magda, Stefania
Florescu, Maria
Bociaga, Zbigniew
Ciobanu, Andrea O.
Kruszynska, Ewa
Dudek, Krzysztof
Vinereanu, Dragos
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 25 (02): : 263 - 272
[30] Left ventricular hypertrophy and diastolic function in patients with severe arterial hypertension
Radchenko, G.
Sirenko, Yu.
Potashev, S.
Kushnir, S.
Kudina, J.
Ponamareva, G.
JOURNAL OF HYPERTENSION, 2007, 25 : S41 - S42

← 1 2 3 4 5 →