Chemokine/Chemokine Receptor Interactions in Extramedullary Leukaemia of the Skin in Childhood AML: Differential Roles for CCR2, CCR5, CXCR4 and CXCR7

被引：42
|
作者：
Faaij, Claudia M. J. M. [1 ]
Willemze, Annemieke J. [1 ]
Revesz, Tom [2 ]
Balzarolo, Melania [1 ]
Tensen, Cornelis P. [3 ]
Hoogeboom, Manja [1 ]
Vermeer, Maarten H. [3 ]
van Wering, Elisabeth [4 ]
Zwaan, Christian M. [5 ]
Kaspers, Gertjan J. L. [6 ]
Story, Colin [2 ]
van Halteren, Astrid G. S. [1 ]
Vossen, Jaak M. [1 ]
Egeler, R. Maarten [1 ]
van Tol, Maarten J. D. [1 ]
Annels, Nicola E. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Paediat, Div Immunol Haematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands
[2] Womens & Childrens Hosp, Dept Haematol Oncol, Adelaide, SA, Australia
[3] Leiden Univ, Med Ctr, Dept Dermatol, NL-2300 RC Leiden, Netherlands
[4] DCOG, The Hague, Netherlands
[5] Sophia Childrens Univ Hosp, Erasmus MC, Rotterdam, Netherlands
[6] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 02期
关键词：
AML; chemokines; paediatric haematology/oncology; ACUTE MYELOID-LEUKEMIA; CHEMOKINE RECEPTOR; EXPRESSION; CELLS; SURVIVAL; INFILTRATION; DIAGNOSIS; CHILDREN; AMD3100; BLASTS;
D O I：
10.1002/pbc.22500
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer 2010;55:344-348. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：344 / 348
页数：5
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