Chemokine/Chemokine Receptor Interactions in Extramedullary Leukaemia of the Skin in Childhood AML: Differential Roles for CCR2, CCR5, CXCR4 and CXCR7

被引：42
|
作者：
Faaij, Claudia M. J. M. [1 ]
Willemze, Annemieke J. [1 ]
Revesz, Tom [2 ]
Balzarolo, Melania [1 ]
Tensen, Cornelis P. [3 ]
Hoogeboom, Manja [1 ]
Vermeer, Maarten H. [3 ]
van Wering, Elisabeth [4 ]
Zwaan, Christian M. [5 ]
Kaspers, Gertjan J. L. [6 ]
Story, Colin [2 ]
van Halteren, Astrid G. S. [1 ]
Vossen, Jaak M. [1 ]
Egeler, R. Maarten [1 ]
van Tol, Maarten J. D. [1 ]
Annels, Nicola E. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Paediat, Div Immunol Haematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands
[2] Womens & Childrens Hosp, Dept Haematol Oncol, Adelaide, SA, Australia
[3] Leiden Univ, Med Ctr, Dept Dermatol, NL-2300 RC Leiden, Netherlands
[4] DCOG, The Hague, Netherlands
[5] Sophia Childrens Univ Hosp, Erasmus MC, Rotterdam, Netherlands
[6] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 02期
关键词：
AML; chemokines; paediatric haematology/oncology; ACUTE MYELOID-LEUKEMIA; CHEMOKINE RECEPTOR; EXPRESSION; CELLS; SURVIVAL; INFILTRATION; DIAGNOSIS; CHILDREN; AMD3100; BLASTS;
D O I：
10.1002/pbc.22500
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer 2010;55:344-348. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：344 / 348
页数：5
相关论文
共 50 条
  • [31] Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals
    Ostrowski, MA
    Justement, SJ
    Catanzaro, A
    Hallahan, CA
    Ehler, LA
    Mizell, SB
    Kumar, PN
    Mican, JA
    Chun, TW
    Fauci, AS
    JOURNAL OF IMMUNOLOGY, 1998, 161 (06): : 3195 - 3201
  • [32] Influence of Acyclic Nucleoside Phosphonate Antivirals on Gene Expression of Chemokine Receptors CCR5 and CXCR4
    Potmesil, P.
    Holy, A.
    Zidek, Z.
    FOLIA BIOLOGICA, 2015, 61 (01) : 1 - 7
  • [33] The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer
    Weitzenfeld, Polina
    Ben-Baruch, Adit
    CANCER LETTERS, 2014, 352 (01) : 36 - 53
  • [34] Chemokine receptor CCR2/CCR5 polymorphism in Spanish patients with systemic lupus erythematosus
    Aguilar, F
    Núñez-Roldán, A
    Torres, B
    Wichmann, I
    Sánchez-Román, J
    González-Escribano, MF
    JOURNAL OF RHEUMATOLOGY, 2003, 30 (08) : 1770 - 1774
  • [35] Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma
    Jahnke, K
    Coupland, SE
    Na, IK
    Loddenkemper, C
    Keilholz, U
    Korfel, A
    Stein, H
    Thiel, E
    Scheibenbogen, C
    BLOOD, 2005, 106 (01) : 384 - 385
  • [36] Expression of the CXCR4 and CCR7 chemokine receptors in human endometrial cancer
    Kodama, J.
    Hasengaowa
    Seki, N.
    Kusumoto, T.
    Hiramatsu, Y.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2007, 28 (05) : 370 - 375
  • [37] Expression of the chemokine receptors CXCR4, CXCR5 and CCR7 in primary central nervous system lymphoma
    Jahnke, K
    Coupland, S
    Na, I
    Loddenkemper, C
    Keilholz, U
    Korfel, A
    Stein, H
    Thiel, E
    Scheibenbogen, C
    ANNALS OF ONCOLOGY, 2005, 16 : 166 - 166
  • [38] Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survival
    de Broek, IV
    Leleu, X
    Schots, R
    Facon, T
    Vanderkerken, K
    Van Camp, B
    Van Riet, I
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2006, 91 (02): : 200 - 206
  • [39] Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis
    Gill, Kevin S.
    Mehta, Kritika
    Heredia, Jeremiah D.
    V. Krishnamurthy, Vishnu
    Zhang, Kai
    Procko, Erik
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (10)
  • [40] Primary HIV isolates that are dual-tropic for the chemokine receptors ccR5 and cxcR4 (fusin, lestr).
    Blatner, G
    Blair, P
    June, C
    Cohen, D
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 14 (04): : 53 - 53
12345