Production of teicoplanin by a mutant of Actinoplanes teicomyceticus

被引：14

作者：

Lee, JC

Park, HR

Park, DJ

Son, KH

Yoon, KH

Kim, YB

Kim, CJ

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[2] Woosong Univ, Sch Food Sci & Biotechnol, Taejon, South Korea

[3] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 07期

关键词：

Actinoplanes teicomyceticus; Diaion HP-20; fermentation; mutation; teicoplanin;

D O I：

10.1023/A:1022842203917

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l(-1) using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l(-1) in 5-1 jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.

引用

页码：537 / 540

页数：4

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