Production of teicoplanin by a mutant of Actinoplanes teicomyceticus

被引：14
|
作者：
Lee, JC
Park, HR
Park, DJ
Son, KH
Yoon, KH
Kim, YB
Kim, CJ
机构：
[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea
[2] Woosong Univ, Sch Food Sci & Biotechnol, Taejon, South Korea
[3] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea
来源：
BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 07期
关键词：
Actinoplanes teicomyceticus; Diaion HP-20; fermentation; mutation; teicoplanin;
D O I：
10.1023/A:1022842203917
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l(-1) using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l(-1) in 5-1 jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.
引用
收藏
页码：537 / 540
页数：4
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