Isolation and NMR Characterization of Fumonisin B2 and a New Fumonisin B6 from Aspergillus niger

被引：87
|
作者：
Mansson, Maria [1 ]
Klejnstrup, Marie Louise [1 ]
Phipps, Richard K. [1 ]
Nielsen, Kristian F. [1 ]
Frisvad, Jens C. [1 ]
Gotfredsen, Charlotte H. [2 ]
Larsen, Thomas O. [1 ]
机构：
[1] Tech Univ Denmark, Ctr Microbial Biotechnol, Dept Syst Biol, DK-2800 Lyngby, Denmark
[2] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2010年 / 58卷 / 02期
关键词：
Fumonisins; Aspergillus niger; mycotoxins; food safety; NMR; MASS-SPECTROMETRY; FUSARIUM-MONILIFORME; CYTOTOXICITY ASSAYS; ION-TRAP; MYCOTOXINS; METABOLITES; CULTURES; PROLIFERATUM; ANALOGS; FUNGI;
D O I：
10.1021/jf902834g
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
A new fumonisin, fumonisin B-6 (1), has been isolated by cation-exchange and reverse-phase chromatography, together with fumonisin B-2 (2), from,stationary cultures of the fungus Aspergillus niger NRRL 326. Analysis of mass spectrometric and NMR data determined that FB6 is a positional isomer of FBI and iso-FB1, having hydroxyl functions at C3, C4, and C5. Analysis of the NMR data for FB2 showed very similar chemical shift values when compared to an authentic Fusarium FB2 standard, strongly indicating identical molecules despite that an absolute stereochemical assignment of FB2 from A. niger was not possible.
引用
收藏
页码：949 / 953
页数：5
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