Plasmodium vivax:: Genetic diversity of the apical membrane antigen-1 (AMA-1) in isolates from India

被引：33
|
作者：
Rajesh, Vidya
Elamaran, M.
Vidya, S.
Gowrishankar, M.
Kochar, Dhanpat
Das, Ashis [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Biol Sci, Pilani 333031, Rajasthan, India
[2] SP Med Coll, Bikaner, India
来源：
EXPERIMENTAL PARASITOLOGY | 2007年 / 116卷 / 03期
关键词：
AMA-1; Plasmodium vivax; genetic diversity; polymorphism; India;
D O I：
10.1016/j.exppara.2007.01.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that apical membrane antigen-1 (AMA-1) is an effective target for eliciting a protective immune response in humans and other experimental animals. We have investigated the sequence variation in Plasmodium vivax AMA-1 (Pv AMA-1) from different Indian isolates. This is the first study of its kind for the nearly full length Pv AMA-1 from India. Our analysis reveals greater degree of genetic diversity in Pv AMA-1 than reported so far and identifies five novel haplotypes. This is significant to establish the antigenic repertoire of isolates in a malaria endemic country like India. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：252 / 256
页数：5
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