Plasmodium vivax:: Genetic diversity of the apical membrane antigen-1 (AMA-1) in isolates from India

被引：33

作者：

Rajesh, Vidya

Elamaran, M.

Vidya, S.

Gowrishankar, M.

Kochar, Dhanpat

Das, Ashis ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Biol Sci, Pilani 333031, Rajasthan, India

[2] SP Med Coll, Bikaner, India

来源：

EXPERIMENTAL PARASITOLOGY | 2007年 / 116卷 / 03期

关键词：

AMA-1; Plasmodium vivax; genetic diversity; polymorphism; India;

D O I：

10.1016/j.exppara.2007.01.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that apical membrane antigen-1 (AMA-1) is an effective target for eliciting a protective immune response in humans and other experimental animals. We have investigated the sequence variation in Plasmodium vivax AMA-1 (Pv AMA-1) from different Indian isolates. This is the first study of its kind for the nearly full length Pv AMA-1 from India. Our analysis reveals greater degree of genetic diversity in Pv AMA-1 than reported so far and identifies five novel haplotypes. This is significant to establish the antigenic repertoire of isolates in a malaria endemic country like India. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：252 / 256

页数：5

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